Welcome to the 

Biostructural Interactions Group!

We study the molecular mechanisms and motions of (membrane) proteins from microorganism to man

Lab News!

11/2022 - It's spooooky!!! Our traditional pumpkin carving was a blast! 

10/2022 - Welcome Nilüfer, Sabine and Tom for your internships/MSc theses! Exciting times ahead for membrane proteins in microbial communication!

09/2022 - Congratulations Vivien for submitting your Bachelor thesis on the many mysteries of pathogenic  trypanosomatid redox enzyme complex formation!

09/2022 - A warm welcome to Guneet, who joins us as a PhD student! Great to have you here and all the best for your project on the structural dynamics of TRP channels!  

08/2022 - Wonderful garden party enjoying the last days of summer together with our friends from the Stallforth Lab! 

08/2022 - Sabrina submitted her Bachelor thesis on ABC transporter function and dynamics! Congratulations!

New Publications!

New collaborative papers with the Friedland lab (Mainz) on TRPC6 accepted in Molecular Psychiatry, with the Sotriffer and Schindelin labs (Würzburg) on p97 in Communications Chemistry and the Zygmunt lab (Lund) on TRPV2 in Nature Communications! Congratulations to Mai and Christoph from our lab and all co-authors!

New review with Stallforth, Mittag, Brakhage and Hertweck labs accepted in TiBS - "Functional Modulation of Chemical Mediators in Microbial Communities"

After TRPV4, Christoph and Bene now also took a hard look at the TRPV1, V2 and V3 intrinsically disordered regions. Paper accepted in Biomol NMR Assign.


Three more TRPV4 papers accepted - with the Sumner lab we looked at mixed channelopathy phenotpes (Ann. Clin. Transl. Neurol.) and post-translational modifications (J. Biol. Chem.), while Bene analyzed the extent of intrinsic disorder in the channel N-terminus using sequence-based predictions and NMR (Biomol NMR Assign.)

Awards and Recognitions!

Our lab is now part of three collaborative research centers funded by the DFG! CRC 1127 'ChemBioSys - Chemical Mediators in Complex Biosystems';  CRC 1278 'PolyTarget -  Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies' and  CRC 1507 'Membrane-associated Protein Assemblies, Maschineries and Supercomplexes'! 

Eric is selected to join the  

TrypsSchool (Sao Paulo School of Advanced  Science on Pathogenic Trypanosomatids)! Congratulations! 

Ute is a new member of the selection committee for the Carl-Duisberg-Gedächtnispreis awarded by the GDCh!

We are super psyched to have been asked to write the preview for the Moiseenkova-Bell lab's structure of the first fungal TRP channel in Structure! Read their paper here and our highlight here!

How to find us:

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Hellmich Group 

Biostructural Interactions
 

Contact us:
Office: Katja Konscholky
katja.konscholky[at]uni-jena.de
03641-9-48760

Lab: Sabine Häfner, Hannah Niederlechner
sabine.haefner[at]uni-jena.de
hannah.niederlechner[at]uni-jena.de
 03641-9-4876-6/-7 

Friedrich-Schiller-Universität Jena

Faculty of Chemistry and Earth Sciences
Institute of Organic and Macromolecular Chemistry
Cluster of Excellence "Balance of the Microverse"

Beutenberg Labs:
Bioinstrumentezentrum (BIZ)
Modul 2, Ebene 4
Winzerlaer Str. 2, 07745 Jena

IOMC Labs:
K018/19
Humboldtstrasse 10, 07743 Jena