human TRPML2 channel extracytsolic/lumenal domain
at different pH values
 (X-ray, 6HRS, 6HRR)

spider silk N-terminal domain

TRPV4 ion channel proline rich region in complex with PACSIN3-SH3 domain 
'skipped class 1 motif'
(NMR, 6F55)

Covalent inhibitor induced dimerization of T. brucei oxidoreductase tryparedoxin
(X-ray, 6GXY, 6GXG)

Lanthipeptide immunity protein SpaI from B. subtilis

Pro-rhodesain, the main
T. brucei lysosomal protease 
(X-ray, 7AVM)

L. lactis lanthipeptide immunity protein, C-terminal domain
(NMR, 2N32)

Structure of an intracellular pathogen infectivity factor in complex with an inhibitor 
(X-ray, unpublished)

References for structures shown above:


Johé, P., Jaenicke, E., Neuweiler, H., Schirmeister, T., Kersten, C., Hellmich, U.A (2021) Structure, interdomain dynamics and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes.

J. Biol. Chem., in press 

Heiby*, J., Goretzki*, B., Johnson, C., Hellmich#, U.A., Neuweiler#, H. (2019) Methionine in a protein hydrophobic core drives tight interactions required for assembly of spider silk.
Nature Commun. 10(1):4378.  doi: 10.1038/s41467-019-12365-5. (*shared first authors, #corresponding authors)

Wagner, A., Le, T.A., Brennich, M., Klein, P., Bader, N., Diehl, E., Paszek, D., Weickhmann, A.K., Dirdjaja, N., Krauth-Siegel, R.L., Engels, B., Opatz, T., Schindelin, H., Hellmich, U.A. (2019) Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes. Angewandte Chemie Int. Ed. 58(11):3640-3644. doi: 10.1002/anie.201810470

Viet, K.K., Wagner, A., Schwickert, K., Hellwig, N., Brennich, M., Bader, N., Schirmeister, T., Morgner, N., Schindelin, H., Hellmich, U.A. (2019) Structure of the human TRPML2 ion channel extracytosolic/lumenal domain. Structure, 27(8):1246-1257. doi: 10.1016/j.str.2019.04.016.

Goretzki, B., Glogowski, N.A., Diehl, E., Duchardt-Ferner, E., Hacker, C., Gaudet, R., Hellmich, U. A. (2018) Structural basis of TRPV4 N-terminus interaction with Syndapin/PACSIN1-3 and PIP2. Structure, 26(12):1583-1593. doi: 10.1016/j.str.2018.08.002

Hacker, C., Christ, N. A., Duchardt-Ferner, E., Korn, S., Göbl, C., Berninger, L., Düsterhus, S., Hellmich, U. A., Madl, T., Kötter, P., Entian, K., Wöhnert, J. (2015) The solution structure of the lantibiotic immunity protein NisI and its interactions with nisin. J. Biol. Chem.290(48):28869-86.

Christ, N.A., Bochmann, S., Gottstein, D., Duchardt-Ferner, E., Hellmich, U.A., Düsterhus, S., Kötter, P., Güntert, P., Entian, K.D. and Wöhnert, J. (2012) The first structure of a LanI protein, SpaI: The protein conferring autoimmunity against the lantibiotic subtilin in Bacillus subtilis reveals a novel fold.  J. Biol. Chem. 287(42):35286-98.